Dr. Yasiini Nuwamanya

Dr. Yasiini Nuwamanya

MBChB (MUK), MPH (MUST), PGD Clinical Trials
(UM, France), Advanced Field Epidemiology
Fellowship (UPHFP)
Email: ynuwamanya@uniph.go.ug/yasinuwamanya@gmail.com
Telephone: +256 773120564/+256 701192437

Host Site: Uganda National Expanded Program on Immunization (UNEPI), Ministry of Health

Host Mentor: Dr. Atugonza Ritah

ABOUT THE FELLOW

Now a polished field epidemiologist, I hold a  Master of Public Health degree, a postgraduate  Diploma in Clinical Trials, and a Bachelor of  Medicine and Bachelor of Surgery degree with  a strong background in the public health sector.  I have a particular interest in infectious disease  epidemiology, vaccines, and immunization.

During the fellowship I was hosted at the Uganda  National Expanded Program on Immunization  (UNEPI); recently rebranded into the Vaccines and  Immunization Division of the Ministry of Health.  The vision of UNEPI is a Ugandan population that  is free of vaccine-preventable diseases with  a mission to reduce morbidity, mortality, and  disability due to vaccine-preventable diseases

in Uganda. The major goal is to ensure that every  child and high-risk group is fully vaccinated with  high-quality and effective vaccines against the

target diseases in line with the recommended  strategies.


  Achievements at the Host Site

At UNEPI, I supported the data and surveillance  subcommittee, participating in various projects  and activities such as outbreak investigation and

response, evaluation of the routine immunization  program performance, support supervision and mentorship, development of policy documents,
grant writing, and scientific communication as
highlighted below:
I started the quarterly public health bulletin for UNEPI, facilitating the timely dissemination of public health information and social mobilization. The bulletin was pivotal in mobilizing for mass vaccination campaigns, including the second phase of the first-ever national preventive yellow
fever mass vaccination campaign in April 2024, and the Big Catch-Up vaccination exercise in November 2024. As managing editor, I developed the concept for the UNEPI bulletin and successfully sourced funding from the Infectious Diseases Institute (IDI) with the support of the UNEPI program manager to kick-start the production. I have since overseen the publication of two issues of the bulletin from February to October 2024.

I authored three articles and co-authored several in the UNEPI quarterly bulletin including:

– Effect of PCV10 on Trends of Pneumococcal

Meningitis in Children Under Five Years,  Uganda, 2003–2022

– Performance of the National Expanded  Programme on Immunization by Antigen – Persistent gaps in immunization coverage:  closing the gaps using Quality Improvement  Approaches

– Integrated Child Health Days (ICHDs)  postponed to November 2024: Fast-tracking  the Big Catch-Up Vaccination Exercise

– Updated Routine Immunization Schedule: Key  Messages for stakeholders

  • Rotavirus vaccine planned switch from Rotarix  to Rotasiil: Introducing a 3-dose Rotavirus  vaccine schedule
  • Uganda Yellow Fever Preventive Mass  Vaccination Campaign Phase 2, April 2-8, 2024

I contributed to the development of an operational  plan for the nationwide ‘Big Catch-Up’ vaccination  exercise that aimed to ensure that 90% of the  eligible population were up-to-date with their  routine immunization.

Subsequently, I supervised the implementation  of the Big Catch-up in Mubende District in North  Central Uganda, overseeing a successful exercise.

I led measles outbreak investigations in Budaka,  Butebo, Terego, and Sembabule districts;  determining outbreak magnitude and risk  factors. The findings informed subsequent mass  vaccination campaigns and interventions to  strengthen routine immunization in the districts.  After the measles outbreak investigations, I  oversaw the mass measles-rubella vaccination  campaigns across all four districts, excelling at the  national target of 95% coverage and successfully  controlling outbreaks.

I took part in developing the operational plan for  phase 2 of Uganda’s Yellow Fever Preventive Mass  Vaccination Campaign. Specifically, I served as  an editor for the accompanying field guide and  talking points tailored for various stakeholders,  including district health teams and implementing  partners. Additionally, I compiled the technical  package for national supervisors, which became  a key reference for training and implementation of  the YFPMVC at the district level.

I led a readiness assessment for the second phase  of the national Yellow fever mass vaccination  campaign across three districts in

western  Uganda—Bushenyi, Mitooma, and Rubirizi— supporting their preparations for a successful

vaccination campaign. During the implementation,  I served as the national supervisor for Kyotera  District, which emerged among the eighth best performing districts, achieving 83% coverage  compared to the national average of 75%.

I participated in the revision of the national EPI  Health Management Information Systems (HMIS)  tools. Specifically, I recommend a birth cohort based child health register for better longitudinal  data capture which was adopted in the new EPI  HMIS tools.

I co-led the monitoring and evaluation of the  effectiveness of the Tickler Box innovation in  Luwero District and Smart Paper Technology in  Masindi District in reducing immunization dropout  rates.

I contributed to an article in the Ministry of  Health report to H.E. the president of Uganda,  on the performance of routine immunization  programs. Specifically, my article highlighted the  pneumococcal conjugate vaccine’s impact on  bacterial meningitis trends in children under five.

I analyzed the spatial distribution of suspected  measles outbreaks in Uganda to inform targeted  and proactive interventions by the Uganda  National Expanded Program on Immunization  including the development of the national measles  preparedness and response plan, 2024.

I contributed to the Health System Strengthening III GAVI grant application, which was successfully  awarded. Specifically, I participated in responding  to reviewers’ comments and refining the  document.

I served as the deputy team lead for the  Hoima health region during the WHO-led Post Introduction Evaluation (PIE) of new vaccines  introduced in Uganda’s routine immunization  system for children under 2 years in 2022,  focusing on Masindi and Kiryandongo districts. I  contributed to data collection tool review, report  writing, and findings dissemination to national  immunization stakeholders.

I attended and actively participated in majority of  the scheduled UNEPI and subcommittee meetings  during which I made several presentations of my  work on data and surveillance and contributed to  discussions on other topics.

In recognition of my expertise and contributions  to the immunization program, I was nominated  to the National Certification Committee on Polio  Eradication (NCC) for Uganda, which consists of  independent experts responsible for assessing  and verifying national documentation on polio-free  status and reporting to WHO regional certification  committee with improvement recommendations.


Fellowship program specific achievements

In addition to leading three measles outbreak  investigations under the host site, I led three others  as part of my assignments during the fellowship.  – Food poisoning at a funeral in Buyengo Town  Council, Jinja District, February 2024

– Anthrax outbreaks in Western Uganda District,  April 2023, during which I investigated the role  of illegal meat dealers in spreading human  anthrax infections

– Measles outbreak in Sembabule District, July August 2024

Participated in six other outbreak

investigations:

– Anthrax outbreak in Ibanda District, April 2024,  during which I led the investigation of illegal  meat dealers in spreading anthrax infections

– Measles outbreak in Bundibugyo District, 2023 – Cholera outbreak in Kayunga District, 2023 – Measles outbreak in Terego District, 2024 – Multi-Drug Resistant TB outbreak in Kayunga  District, 2024

– Mpox outbreak in Kampala Metropolitan area  (Kampala, Wakiso and Mukono districts), 2024

Analyzed pediatric bacterial meningitis sentinel  surveillance data and assessed the effect of  10-valent pneumococcal conjugate vaccine on  the trends of pneumococcal meningitis among

children under 5 in Uganda from 2003─2022, to  generate evidence of the effectiveness of the

PCV10 routine immunization program.

Presented at six local conferences during  2023-2024

– Anthrax outbreaks in Western Uganda: the  role of illegal meat dealers in spreading  the infection at the 9th National Field  Epidemiology Conference, November 2023,  and the National Quality Improvement  Conference, March 2024.

– Effect of 10-valent pneumococcal conjugate  vaccine on the trends of pneumococcal  meningitis among children under five years in  Uganda, at the 23rd conference of the Uganda  Society of Health Scientists, August 2024,  and National Health Promotion Conference,  October 2024.

– Food poisoning outbreak caused by  Aeromonas bacteria at a funeral in Jinja  District, at the 18th Joint Annual Scientific  Health Conference, October 2024, and  the 10th National Field Epidemiology and  2nd Laboratory Leadership Conference,  November 2024.

I led the protocol development for the  national immunization coverage mini-survey to  evaluate the routine immunization program and  determine factors associated with the uptake of  immunization services in Uganda. Subsequently,  I won a grant of 85,000 USD from the US CDC  in partnership with IDI for the Uganda National  Institute of Public Health (UNIPH) to conduct the  survey. I successfully coordinated the survey in all  the fifteen designated health regions of Uganda,  during August-September 2024.

Presented to two international audiences

– Anthrax outbreaks in Western Uganda: the  role of illegal meat dealers in spreading the  infection, to the Global Health Center (GHC),  US Centers for Disease Control and Prevention  (CDC) Web and Content Development  Team in CDC Atlanta. The presentation  was incorporated into a documentary  showcasing work done with funding from the  US government for presentation to the US

congress, in July 2024.

– Cost-effectiveness of preventive strategies  for human anthrax infections in Uganda, during  the international Data-to-Policy technical  exchange session organized by Vital Strategies  in collaboration with CDC foundation,  November 2024.

Excellence awards 

– Best abstract at the 23rd conference of the  Uganda Society of Health Scientists, August  2024

– Best poster presentation at the 18th Joint  Annual Scientific Health Conference, October  2024

Mentor for the fifth cohort of the Intermediate  Field Epidemiology Training Program.

Wrote and published two newspaper articles in  the New vision

– Prevent liver cancer; get vaccinated against  Hepatitis B!

– Save your child from brain dysfunction;  vaccinate against meningitis now!

Editor for Issue 1 of volume 9 of the quarterly  Uganda Public Health Bulletin; a public health communication channel ran by the Uganda  National Institute of Public Health.

I am a lead author of five articles in the Uganda  Public Health Bulletin; a national public health  communications channel run by UNIPH. These  included:

– Anthrax outbreak in Western Uganda: the role  of illegal meat dealers in spreading infection,  August 2022─April 2023

– Food poisoning caused by Aeromonas  bacteria at a funeral in Buyengo Town Council  Jinja District, February 2024

– Uganda switches from Rotarix rotavirus  vaccine to Rotasiil: Introducing a 3-dose  Rotavirus vaccine schedule into the routine  immunization program, March 2024

– Uganda Yellow Fever Preventive Mass  Vaccination Campaign Phase 2, April 2-8, 2024 – World Health Awareness Days, and  International Health Days, for April-June

2024: International Cesarean Awareness  Month, April 1-30, World Hemophilia Day,  April 17, World Malaria Day, April 25, World  Immunization week April 1-30, World Asthma  Day, May 7, World Hypertension Day, May 17,  World Preeclampsia Day, May 22, World Blood  Donor Day, June 9,

and World Sickle Cell Day,  June 19.

Implemented a Quality Improvement Project  on reducing the dropout between the first and  second doses of measles-rubella vaccine, among  children aged 18-59 months at Masaka Regional  Referral Hospital, Uganda, July–December 2024.

Conducted an epidemiological study on  predictors of Mortality among Children <5 years  Admitted with Bacterial Meningitis at Pediatric  Bacterial Meningitis Sentinel Surveillance Sites,  Uganda, 2003–2022.

Led a TB/HIV epidemiological study on Interval  from TB diagnosis and treatment initiation, and  factors associated with treatment outcomes  among TB patients in high-volume health facilities  in North-Central Uganda, 2018-2022.

Research supervisor for the household survey  on excess mortality due to COVID-19 in Uganda,  March-April 2023.

Wrote two policy briefs

– Reducing Mortality from Snakebite  Envenoming in Uganda, A policy brief

– Cost effectiveness of prevention strategies  for human anthrax in Uganda

Publications in peer-reviewed journals

– Lead author of an article titled “Effect of  10-valent pneumococcal conjugate vaccine  on trends of pneumococcal meningitis  among children under five years in Uganda,  2003-2022”, that was published in the BMC  infectious diseases Journal.

– Co-authored a manuscript titled “Ebola  disease outbreak caused by the Sudan virus in  Uganda, 2022: a descriptive epidemiological  study” that was published in the Lancet journal.

– Lead author for a manuscript titled “Food  poisoning outbreak caused by Aeromonas bacteria at a funeral in Buyengo Town Council  Jinja District, February 2024”, currently under  peer-review in the BMC infectious diseases  Journal.

– Lead author for two other manuscripts titled  ‘predictors of Mortality among Children <5 years  Admitted with Bacterial Meningitis at Pediatric  Bacterial Meningitis Sentinel Surveillance Sites,  Uganda, 2003–2022’ and “Anthrax outbreaks  in Western Uganda: the role of illegal meat  dealers in spreading the infection” are under  internal review.


Summary of Epidemiological Study: 

 Title: Effect of 10-valent pneumococcal conjugate  vaccine on the trends of pneumococcal  meningitis among children under five years in  Uganda 


Background: Pneumococcal meningitis,  a vaccine-preventable disease caused by  Streptococcus pneumoniae (Spn) is the leading  bacterial meningitis in Under Five children. In April  2014, Uganda introduced routine immunization  with 10-valent Pneumococcal Conjugate Vaccine  (PCV10) for infants. The target coverage for herd  immunity is ≥90% with three doses (PCV10-dose  3). We assessed the effect of PCV10 introduction  and coverage on the trends of pneumococcal  meningitis in under five children.

Methods: We analyzed laboratory-confirmed  pediatric bacterial meningitis (PBM) data at  two high-volume WHO-accredited sentinel  surveillance hospitals in Kampala City and Gulu  District, from 2003–2022. We used confirmed  cases to estimate the minimum incidence of  pneumococcal meningitis in the host districts and  calculated annual incidence of pneumococcal  meningitis per one million populations, and the  proportion of confirmed PBM attributable to  Spn. We divided the study period into 2003– 2013 (pre-PCV10) and 2014–2022 (post-PCV10),  and conducted interrupted time series analysis  using autoregressive integrated moving average  models for the effect of PCV10 on trends of  pneumococcal meningitis and PBM attributable to  Spn. We analyzed reported PCV10 data in DHIS2  from 2014–2022 for annual PCV10-dose 3 coverage. Results: Among the 534 confirmed PBM cases,  331(62%) were pneumococcal meningitis;  227(69%) from Gulu District and 104(31%) from  Kampala City. The majority (95%) of the isolates  were not serotyped. The majority (57%) were male  and unimmunized (98%); median age=14(IQR=6-27)  months with most (55%) aged ≥12 months. The case fatality rate was 9%. During Pre-PCV10 period, the  overall incidence of pneumococcal meningitis  in the host districts increased; slope change=1.0  (95%CI= 0.99999, 1.00001). which declined in post PCV10 period (2014–2022) by 92% from 86 cases  /1,000,000 in 2014 to 7/1,000,000 in 2022, slope  change= -1.00006 (95%CI=-1.00033, -0.99979).  Whereas there was an immediate decline in  the proportion of confirmed PBM attributable  to Spn in the host districts, level change=- 1.84611(95%CI=-1.98365, -1.70856), an upward trend  was recorded from 2016–2022, slope change=1.0  (95%CI=0.99997, 1.00003). During 2015–2022,  PCV10-dose 3 coverage was largely>90% for Gulu  District and 52-72% for Kampala City.

Conclusion: The PCV10 routine immunization  program reduced the incidence of pneumococcal  meningitis in Kampala City and Gulu District. There  was no effect on the confirmed PBM proportionately  attributable to Spn. Kampala City persistently  recorded PCV10-dose3 coverage<90%. We  recommend enhancing serotyping and periodic  nasopharyngeal carriage surveys to ascertain the  maximum vaccine effectiveness and monitor Spn  serotypes, and strengthening routine immunization  in Kampala City.


Key lessons learnt during the fellowship

During the fellowship, I learnt and developed the  following skill sets:

  • Outbreak Investigation and response  including designing and instituting appropriate  interventions
  • Designing and conducting epidemiological  studies
  • Evaluation of public health surveillnce systems
  •  Designing and implementing Quality  Improvement Projects
  • Decision modelling for health econmonic  evaluation
  • Scientific writing including writing abstracts,  and manuscripts
  • Writing policy briefs
  • Designing and writing for public health  bulletins
  • Non-scientific communication including  writing newspaper articles
  • Data management, analysis and interpretation  using such sofware as STATA, Epi-Info, Excel  and Quantum Geographic Information System  (QGIS)
  • Presentation skills and dissemination of  scientific findings
  • Mentorship skills
  • Team leadership and coordination skills
  • Networking and lobbying skills

Next Steps

Working with the Ministry of Health and/or  partner organizations, I hope to use my newly  acquired skills and knowledge to advance  Uganda’s health security agenda, by strengthening  public health surveillance to ensure prompt  detection and control of outbreaks at source. I  also intend to use my mentorship skills to build  capacity of fellow health workers in public health  surveillance in Uganda and beyond; with particular  emphasis on routine health data use. Above all, I  am looking forward to furthering my career as a field epidemiologist for maximum contribution to  towards the attainment of Global Health Security.


Pictorial

Meeting the Chairperson and DHO of Rubirizi
District to strategize for the Yellow Fever
Preventive Mass Vaccination Campaign at
Rubirizi District, March 2024

Mentoring Masaka City District and HSD
surveillance teams on electronic Disease
Surveillance and Response (eIDSR),
September 2024

Making a conference presentation at the 10th
National Field Epidemiology Conference,
November 2024

Brainstorming session with the QI team during root cause analysis for the high MR1-MR2 at Masaka Regional Referral Hospital, June 2024

Responding to a comment from the audience
during the dissemination of preliminary findings of the national immunization coverage mini-survey at Uganda WHO offices, December 2024

Happy mentor: pausing for a photo with my mentees under cohort 5 of the Intermediate Field Epidemiology Training Program (IFETP-Intermediate) at their graduation ceremony at the Source of the Nile Hotel, Namanve, Wakiso District, September 2024

Presenting at the 23rd conference of the Uganda
Society of Health Scientists, August 2024

Receiving the award for the best abstract under
vaccines and immunization at the 23rd conference of the Uganda Society of Health Scientists, August 2024

Receiving the award for the best poster presentation at the 18th joint annual scientific health conference, October 2024

Receiving the certificate of completion of Decision modelling for health economic evaluation at Sheraton Istanbul City Center Hotel, Turkey in October 2024

Interviewing parents who lost two children during the food poisoning outbreak investigation in Jinja District, February 2024

Disseminating preliminary findings of the food
poisoning outbreak investigation to the Jinja
District Task Force, February 2024

Leading community entry during the exces mortality survey in presence of Julie Harris, the
former resident advisor, March 2023